A 14-day maintenance phase then follows and dieters can gulp a green juice plus three sirtfood meals a day. Both Morse and Nestle said the early calorie restriction phase is the real secret to the diet's weight-loss promises.
"They have to be kidding. Anyone would lose weight -- and lots of it -- on 1,500 calories a day, with or without sirtuins," Nestle said. She said it's basically a starvation diet, which can cause muscle mass loss and dehydration.
"Fortunately, the body fights starvation so most people can't stick to low-calorie diets for very long, and a few weeks on this diet shouldn't matter much," Nestle said. Morse said the initial weight loss dieters may experience won't likely be fat loss, but rather a shedding of water weight.
"Most people won't see a fat loss in those early days. Likely it's water. You'll feel slimmer, but it's probably water weight. You can't lose fat in that short an amount of time," Morse explained.
"For a petite woman who is 5 feet tall and not very active, it's not very dangerous, but 1,000 calories would be much too low for a 6-foot-4-inch man to consume," said Morse.
Anyone with a chronic condition such as diabetes, where carbohydrate levels are important to follow, could face more serious health risks, she added.
On the plus side, you can't go wrong with a diet full of vegetables and fruits and good fats (such as those found in nuts and olive oil), Morse said.
"Rocket and parsley and celery and green apples -- those are all really good things. And green tea -- matcha -- has anti-inflammatory properties. There are human studies with green tea. Walnuts are high in healthy fats, fiber and protein," Morse said.
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A study out this week in JAMA Internal Medicine backs up the value of loading up on plant-based proteins.
Massachusetts General Hospital and Harvard Medical School researchers studied the diets of more than 130,000 people and found that eating more protein from plant sources was linked with a lower risk of death. Consuming more protein from animal sources was associated with a higher risk of death, especially among adults who had one or more unhealthy habits such as smoking, drinking or being sedentary.
The Sirtfood Diet also requires lots of food planning and prep time, and Morse said people who plan their meals in advance typically have more weight-loss success.
"I would recommend aspects of this diet, but I personally wouldn't recommend this diet. I guess I don't like the term 'diet.' There's so much failure with diet. You're taught certain short-term goals and how to eat a certain way and then people tend to go off and gain more weight back," Morse said, noting that she prefers an overall lifestyle-based plan that people can stick to for life.
The early "starvation" phase of the diet aside, Nestle also said the plant-heavy eating plan has plusses.
"The foods that are proposed in this diet are excellent choices," she said. "If it helps people who need to lose weight to lose some, I'm for it."
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